people / Francoise Helmbacher

Group Leader
e-mail : Francoise.HELMBACHER [ at ]
Tel : +33 4 91 26 93 45


Research experience

Since 2005:  
        Group leader at IBDM, CNRS UMR7288
        CR1 CNRS Researcher
1999- 2004:
        Post-doc in the laboratory of Rüdiger Klein.
        o 2000-2004: Dpt of Molecular Neurobiology, Max-Planck-Institute of Neurobiology. Martinsried.Germany.
        o 1999-2000: EMBL, Developmental Biology Department.
        PhD in cellular and molecular Biology, Paris 6 University (UPMC)
        Supervisor: Patrick Charnay.
        INSERM U 368. Ecole Normale Supérieure. Paris. France.
        Master (DEA) in cellular and molecular Biology, Paris 6 University (UPMC)
        Supervisor: Patrick Charnay.
        INSERM U 368. Ecole Normale Supérieure. (Paris)

Academic positions, grants and fellowships


- FSH Society Grant : (2015-2017)
- FSHD global research foundation : (2012-2015)
- AFM (Association Francaise contre les myopathies): (2012-2015) 
- FSH Society Post-doctoral fellowship for AK Zimmermann (2013-2015)
- FRM (Fondation pour la recherche médicale): "Equipe FRM 2007" award: (2008-2010)
- ANR-Neuro (Agence Nationale pour la recherche): (2008-2010)
- AFM (Association française contre les myopathies) : 2008-2009 
- Atip plus (CNRS) (2008-2009)
- Fondation de France (2007-2009)
- ARC (Association pour la recherche contre le cancer) (2007-2008)
- AFM (Association française contre les myopathies) : 2005-2006,
- FRC (Fédération pour la recherche sur le cerveau): 2005-2006
- FRM (Fondation pour la recherche médicale): 2005 (start-up)
- ATIP (CNRS) (2005-2007)

Academic positions:
July 2004:                  CNRS CR1 position
2003-2004:                  Max-Planck Stipend
2001-2002:                  Marie-Curie Long term fellowship.
1999-2000:                  Post-doc fellowship from the ARC
1997-1998:                  PhD fellowship from the ARC (French, cancer research).
1995-1997:                  Monitorat, Université Paris 13.
1994-1997:                  PhD fellowship from the French government.

Publication List :
Google scholar profile

- Fan Y, Richelme S, Avazeri E, Helmbacher F, Dono R, and Maina F. Tissue-specific gain of RTK signalling uncovers selective cell vulnerability during embryogenesis. PLoS Genetics, in press (2015)

- Mazdak Bagherie-Lachidan, Antoine Reginensi, Hitisha P. Zaveri, Daryl A. Scott, Françoise Helmbacher and Helen McNeill. Stromal Fat4 acts non-autonomously with Dachsous1/2 to restrict the nephron progenitor pool. Development, june 26, 2015.

- Mariot V, Roche S, Hourdé C, Portilho D, Sacconi S, Puppo F, Rameau P, Caruso N, Delezoide AL, Desnuelle C, Bessières B, Collardeau S, Feasson L, Maisonobe T, Magdinier F, Helmbacher F., Mouly V, Butler-Browne G. Dumonceaux J. Correlation between low FAT1 expression and early affected muscle in FSHD. Annals of Neurology, 2015, MAY 28.

-Puppo F., Dionnet E., Gaillard MC., Gaildrat P., Castro C., Vovan C., Bertaux K., Bernard R., Attarian S., Goto K., Nishino I., Hayashi Y., Magdinier F., Krahn, M., Helmbacher, F., Bartoli, M, and Levy, N.  Identification of variants in the 4q35 gene FAT1 in patients with a Facioscapulohumeral dystrophy (FSHD)-like phenotype. Human Mutation (2015), 23 JAN. DOI: 10.1002/humu.22760

-Caruso N, Herberth B, Lamballe F, Arce-Gorvel V, Maina F, and Helmbacher F. Plasticity versus specificity in RTK signalling modalities for distinct biological outcomes in motor neurons. BMC Biology 2014, 12:56

- Chai G, Zhou L, Manto M, Helmbacher F, Clotman F, Goffinet AM, Tissir F. Celsr3 is required in motor neurons to steer their axons in the hindlimb. Nature Neuroscience (2014), Aug 10. doi:10.1038/nn3784 PMID:25108913

- Caruso N., Herberth B., Bartoli M., Puppo F., Dumonceaux J., Zimmermann A., Denadai S., Lebossé M., Roche S., Geng L., Magdinier F., Attarian S., Bernard R., Maina F., Levy N. and Helmbacher F. (2013). Deregulation of the protocadherin gene FAT1 alters muscle shapes: implications for the pathogenesis of Facioscapulohumeral dystrophy. PLoS Genet 9(6): e1003550.

- Charoy C, Nawabi H, Reynaud F, Derrington E, Bozon M, Wright K, Falk J, Helmbacher F, Kindbeiter K, Castellani V. (2012). gdnf Activates Midline Repulsion by Semaphorin3B via NCAM during Commissural Axon Guidance. Neuron. 2012 Sep 20;75(6) 

- F. Lamballe, M. Genestine, N. Caruso, V. Arce, S. Richelme, F. Helmbacher*, F. Maina*. (2011). Pool-specific regulation of motor neuron survival by neurotrophic support. J. Neurosci. 2011, Aug 3;31(31):11144-58. PMID:21813676. (*co-last and co-corresponding authors). 

- Genestine M., Caricati E., Fico A., Richelme S., Hassani H., Lamballe F., Panzica G., Pettmann B., Helmbacher F., Raoul C., Maina F.* and Dono R.*. (2011). Enhanced neuronal Met signalling levels in ALS mice delay disease onset. Cell Death Dis. 2011 Mar 17; 2:e130. PMID: 21412276

- Gascon E., Gaillard S., Mallapert P, Liu Y., Rodat-Despoix L., Samokhalov I., Delmas P., Helmbacher F., Maina F., Moqrich A. (2010). HGF-Met signaling is required for Runx1 extinction and peptidergic differentiation in primary nociceptive neurons. J Neurosci. 2010. Sep 15; 30(37):12414-12423.

- Kramer E; Knott L; Su F; Dessaud E; Krull CE; Helmbacher F*, and Klein R*. (2006). Cooperation between GDNF/Ret and ephrinA/EphA4 signals for motor axon pathway selection in the limb. Neuron April 6, (2006) 50(1):35-47. (*These authors contributed equally to the work).

- Helmbacher, F., Dessaud, E., Arber, S., deLapeyriere, O., Henderson, C. E., Klein, R. and Maina, F. (2003). Met Signaling Is Required for Recruitment of Motor Neurons to PEA3-Positive Motor Pools. Neuron 39, 767-77.

- Maina, F., Pante, G., Helmbacher, F., Andres, R., Porthin, A., Davies, A. M., Ponzetto, C. and Klein, R. (2001).Coupling Met to specific pathways results in distinct developmental outcomes. Molecular Cell 7, 1293-306.

- Yokoyama, N., Romero, M. I., Cowan, C. A., Galvan, P., Helmbacher, F., Charnay, P., Parada, L. F. and Henkemeyer, M. (2001). Forward signaling mediated by ephrin-B3 prevents contralateral corticospinal axons from recrossing the spinal cord midline. Neuron 29, 85-97.

- Adams, R., Diella, F., Hennig, S., Helmbacher, F., Deutsch, U. and Klein, R. (2001). The cytoplasmic domain of the ligand EphrinB2 is required for vascular morphogenesis but not cranial neural crest migration. Cell 104, 57-69.

- Helmbacher, F., Schneider-Maunoury, S., Topilko, P., Tiret, L. and Charnay, P. (2000). Targeting of the EphA4 tyrosine kinase receptor affects dorsal/ventral pathfinding of limb motor axons. Development 127, 3313-24.

- Helmbacher, F., Pujades, C., Desmarquet, C., Frain, M., Rijli, F. M., Chambon, P. and Charnay, P. (1998). Hoxa1 and Krox-20 synergize to control the development of rhombomere3. Development 125, 4739-48.


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last updated 28.06.2015